And they do so in a situation where they haven't lost since 1996, and are big favorites.
"The last time San Francisco lost in a game where they were favored by 8.5 points or more, was 1996," said Jack Randall of OddsShark.com. "So even though they spot the Bills 10 points on the Vegas spread, recent history and ancient history tells us the 49ers will romp here."
The 49ers have been sharp on both sides of the ball throughout the season.
The Buffalo Bills are looking like their usual mediocre selves through the early stages of the season. The Bills beat both Cleveland and Kansas City by double digits, but against tougher competition in the New York Jets and New England Patriots, they lost by double digits.
Now 2-2 both SU and ATS, Buffalo will need its best effort to compete with San Francisco this week.
Under Head Coach Jim Harbaugh, the San Francisco 49ers haven’t done much other than win. The 49ers are 16-4 SU and 14-5-1 ATS in 20 regular season games under Harbaugh, and have won each of their last seven regular season home games both SU and ATS.
Is Buffalo going to be the team to buck that trend? The Bills are 1-8 SU and 2-6-1 ATS in their last nine games on the road. The offense has performed well this season, averaging 28.8 points per game, but the defense has allowed 32.8 points per game including two games in which it allowed 48+ points.
San Francisco is just too much of a well-oiled machine to bet against. The defense should give Buffalo’s talented offense fits, and the offense should be able to score into the 30s and cover this spread at home.
PICK: San Francisco -10 (courtesy of PickShark.com)