While it will be difficult to rely on many of the Titans' options, if you are faced with injuries, lack of depth or play in a deeper fantasy league, there are still a few players on the Tennessee roster that are worth a look on Sunday.
Jake Locker, Quarterback
After throwing for 403 yards and two touchdowns in his first two games as a starting quarterback, Locker broke out in Week 3, passing for 378 yards and two scores while adding another 35 yards on the ground against the Lions.
Facing a Texans defense with a strong pass rush and one of the top corners in all of football, it's unrealistic to expect Locker to replicate that success on Sunday.
With that said, the Titans are unlikely to have much success running the ball against Houston, leaving the majority of the burden of moving the football on Locker, who could very well go over 40 pass attempts for the second consecutive week.
While Locker may not be a true No. 1 quarterback this week, he is a top-end No. 2 and can still be used as a starter if you are in a pinch. Expect right around 250 yards and two touchdowns from the Titans quarterback.
Chris Johnson, Running Back
Three weeks into the season, Chris Johnson has found himself almost entirely off of the fantasy radar.
After many fantasy players spent a top 10 pick on the former 2,000-yard rusher, he has worked his way onto the bench of most fantasy teams, and for good reason.
Through the first three games, Johnson is averaging just 1.3 yards per carry and has yet to eclipse 25 yards rushing in a game, currently sitting as the 62nd-ranked running back in the league.
Against an elite Texans defense, only the most desperate of owners should look to Chris Johnson as an answer in Week 4.
Kenny Britt, Wide Receiver
After returning to action in Week 2, Kenny Britt saw his first full set of reps last week, catching six of his 11 targets for 55 yards and looking like the Titans' No. 1 receiver moving forward.
However, as has been the case for much of his career, Britt injured his ankle in the fourth quarter and is now questionable for the game on Sunday.
Though he has plenty of fantasy value moving forward, he should be viewed as nothing more than a third receiver in fantasy this week if he is indeed active against the Texans.
Nate Washington, Wide Receiver
Despite getting just three targets in Week 3, Nate Washington was able to make the most of his opportunities, hauling in all three passes for over 100 yards and a spectacular, 72-yard touchdown pass late in the fourth quarter to give the Titans the lead.
With Britt and tight end Jared Cook questionable, Washington will likely slide back into one of the top receiving targets this week.
Though it's tough to rely on Washington against the Texans, if Britt and/or Cook sit out this week, Washington is a solid No. 3 option with the potential to get into the end zone at least once.
Jared Cook, Tight End
Like Britt, Cook is listed as questionable heading into this weekend.
However, Cook seems likely to play on Sunday after being limited in practice on Friday, nursing a sore shoulder.
Cook was off to a very strong start last week against the Lions prior to leaving the game around halftime.
If the Titans are going to have a chance of winning this game, they will need a big day from Cook, who has begun looking more and more like a No. 1 tight end throughout training camp and the early regular season. He should provide fantasy owners with the potential for huge numbers any given Sunday.