That decision, however, does not rest with Bush. It lies with head coach Joe Philbin, and he has not said whether or not Bush will see the field.
Bush has had a career rejuvenation since joining the Miami Dolphins last season and this year has already racked up 302 yards.
So, what should fantasy owners expect from Bush in Week 4 against the Arizona Cardinals?
Even without the injury, the matchup at first may seem overwhelming.
Arizona has been the surprise team of the young year, starting out 3-0 and only allowing 40 points.
That statistic is somewhat misleading, though, as the Cardinals actually only rank 17th in rush defense and have allowed 106 yards per game on the ground.
Assuming Bush plays, he is undoubtedly going to see a limited workload.
The Dolphins have two capable backup options in Daniel Thomas and Lamar Miller. There is no reason to overwork Bush and risk re-injuring his sprained knee.
Thomas can handle though third-down carries and goal-line situations, while Miller is a speedster who is lethal in space.
Bush is obviously the best running back on the depth chart, but the point is that it would be surprising if Miami was anything but hesitant with his return.
Bush has missed 21 games over the past five seasons, and his penchant for minor injuries has to be a cause for concern for the Dolphins organization.
Still, the former USC Trojan and kinda-sorta Heisman Trophy winner is one of the most electric players in all of football.
Miami would be at a severe disadvantage if unable to get him on the field and allow him to create mismatches against the Cardinals defense.
It may be tough to keep one of the NFL's most productive running backs out of your starting lineup this week, but it may turn out to be the right play if you have any other option.
If Philbin decides to let Bush play, Bush is still likely to get more carries than Thomas or Miller, but his overall workload will be a question mark, and the odds of Bush getting goal-line carries are slim.
Even coming off a sprained knee, Bush is always a home-run threat who can net you a 60-plus-yard touchdown, but don't expect his typical 17 to 20 carries this week.