In truth, the Red Devils have looked far from world-class so far this season, but have done surprisingly well considering their reputation for slow-starting campaigns, and thus could be considered early title favourites ahead of table-toppers Chelsea and defending champions Manchester City.
Tottenham are now showing signs of adjusting to new manager Andre Villas-Boas' philosophy and tactical ideas, and proved how devastatingly brilliant they can be at times with their crushing victory away to Reading and professional win at home to London rivals, Queens Park Rangers.
It will be another fascinating game for both teams, as United seek to prove their worth as legitimate title contenders, and Spurs attempt to establish themselves at the elite end of the sport.
Kick-off is at 1730 GMT. Read on for the full match preview.