If there's ever a game where the Saints need Drew Brees to be the Super Bowl MVP that he is, it's this one.
So how will this one turn out?
Below is a full game preview, including spread and betting lines, fantasy advice, game keys and my prediction.
Where: Mercedes-Benz Superdome, New Orleans
When: Sunday, September 23 at 1 p.m. ET
Spread: Saints -9 (Bovada)
Although the Saints have looked uncharacteristically bad so this season, I'd still take the Saints to cover.
Drew Brees & Co. aren't going to let the Chiefs get the best of them in their house, and I expect a big day out of the Saints' offense this Sunday.
Take the Saints here in anticipation of a big day from Brees and the Saints' offense.
Over/Under: 53 (Bovada)
I'm predicting a huge game for the Saints' offense so I'd take the over here.
The Saints have put up 32 and 27 points in the the first two weeks, while Kansas City has scored 24 and 17.
These two offenses shouldn't have much resistance when it comes to scoring points in the dome on Sunday.
To put things into perspective, the line has gone over in five of the Saints last five games, according to Bovada.
This ones going to be an offensive explosion—take the over here.
Key Injuries: (via CBS Sports)
KC TE Kevin Boss—HEAD—QST
KC WR Steve Breaston—WRIST—PRB
KC RB Jamaal Charles—KNEE—PRB
KC S Kendrick Lewis—SHOULDER—QST
KC WR Dexter McCluster—SHOULDER—QST
KC DT Anthony Toribio—ANKLE—QST
NO QB Drew Brees—ANKLE—PRB
NO WR Marques Colston—FOOT—QST
NO S Roman Harper—WRIST—PRB
NO WR Devery Henderson—CONCUSSION—PRB
Big Fantasy Players
Dwayne Bowe was a monster in Week 2 against the Bills when he went off for eight receptions, 102 yards and two touchdowns, much to the liking of his fantasy owners.
The Saints' D allowed 100-plus receiving yards and a touchdown to Washington Redskins WR Pierre Garcon in Week 1 and 104 more yards to Carolina's Steve Smith last Sunday.
NFL.com's Dave Dameshek ranks Bowe as the second-best option at wide receiver for Week 3 of fantasy football.
Bowe is a must-start.
Although Drew Brees has thrown just as many touchdowns as interceptions (4), I still like him to have a huge day on Sunday.
The Chiefs' D let Matt Ryan throw all over them, to the tune of 299 yards and three touchdowns, and Kansas City also made Buffalo QB Ryan Fitzpatrick look like an All-Pro, allowing him an easy 178 yards and two touchdowns.
Brees is playing in his house against a defense that has been dismal against the pass and is practically the No. 1-ranked QB across the board on NFL.com's fantasy page.
It's a no-brainer.
Keys to a Chiefs Win: Keep Brees Off the Field
This is simple for the Kansas City Chiefs: keep Drew Brees on the sidelines.
The Chiefs have a decent offense but not nearly enough to keep up with Brees, who's going to shred the KC defense every chance he gets.
Matt Cassel needs to manage the game and get the ball to his playmakers—Dwayne Bowe and Jamaal Charles—and allow for long, productive drives on offense.
That's the only way KC leaves the dome with a victory.
Key to a Saints Win: Drew Brees, Drew Brees and Drew Brees
Sunday is going to be a breakout performance for Brees and the Saints' offense.
Kansas City has already proved that they can't defend the pass, which just so happens to be New Orleans' specialty.
I expect Brees to utilize Darren Sproles in the passing game and hit his big receivers (Colston, Moore and Graham) to sink the Chiefs this Sunday.
Brees isn't going to allow the Saints to go down 0-3 on the young season.
Expect him to take control and dominate this matchup.
Prediction: Saints 35, Chiefs 17
There's going to be a lot of points scored in this one, with the majority of them coming via Drew Brees' right arm.
The Saints' offense will be too much for the weak KC secondary, giving New Orleans its first win of the season.
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