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This one can't be overlooked.
The defense played as well as any in the league against the Patriots, holding Tom Brady to only one touchdown and forcing an interception. The Eagles have one of the most explosive offenses in the NFL with LeSean McCoy, Michael Vick, and DeSean Jackson. That's a lot of speed to account for and it will be interesting to see how Ray Horton's defense matches up.
A big key to the game will be how the Cardinals' defensive line exploits the Eagles weakness at center. Philadelphia's starting center, Jason Kelce, will have to undergo surgery on a damaged ACL and MCL, so backup Dallas Reynolds will be the starter on Sunday. He handled the job well when he played against the Ravens, but it's always hard to patch up an offensive line.
The Cardinals know that better than anyone.