This Week 2 challenge will be a rematch of a hard-fought game that took place at Ford Field in 2011. The 49ers came away with a 25-19 road win over the Lions in a tense, physical fight between NFC contenders.
For a second straight week, the 49ers will be one of two teams in America's Game of the Week.
On Sunday night, San Francisco will host Detroit in a game that will epitomize the physicality of football. The 49ers are going to have to play a smart football game, executing mentally and physically. The Lions are no doubt bitter over the way the last game ended and will be looking to take their frustrations out in Week 2.
In this piece, we'll breakdown the keys to the game for San Francisco and how they can start 2012 with a 2-0 record.