It is hard to tell how this game will unfold.
On one hand you have the uber-efficient Green Bay offense that led the league in scoring last season at 35 points per game. Then you have a 49ers defense that was downright stingy last year and features some of the biggest names in football in Patrick Willis and Aldon Smith.
In addition to winning the Super Bowl in 2010, Aaron Rodgers proved last season that the Brett Favre era in Green Bay is officially over. While no one will ever take away what Favre meant to the Packers, it isn’t hard to see that Rodgers is on a mission to keep the rich football tradition in Green Bay moving right along.
The 49ers will go as their defense goes. But if the offense plays up to its ability, they could be the most complete team in the NFL.
Here is one bold prediction for each team heading into Sunday's opener.
Randy Moss Has His First 100-Yard Receiving Day since Week 10 of 2009
The 49ers made one of the strangest moves this offseason with the signing of wide receiver Randy Moss.
It was a mystery as to how he would fit into San Francisco's plans, but Moss seems to have gotten over his bullish ego and should be able to find his role with the 49ers this season.
While Moss is no longer the dynamic wideout he once was, his presence should provide a different wrinkle to the 49ers offense and could be what quarterback Alex Smith needs to take that next step in his career.
San Francisco isn't going to change its entire offensive scheme around Moss, but Green Bay finished dead last in the NFL in pass defense last season.
If this game turns into a shootout, Moss could benefit from a couple huge plays downfield.
Aaron Rodgers Throws Three Interceptions, Half of His Total for All of Last Season
Rodgers only threw six interceptions all of last season. But he has to come back down to earth right?
The 49ers defense is unforgiving and finished second in the league with 23 interceptions last season. However, Green Bay will pick up where they left off in 2011 as Rodgers and Co. will continue their aerial assault.
While Rodgers is a cool customer in the pocket, San Francisco's defense will have plenty of chances to rattle him on Sunday.
The constant barrage of pressure will put Rodgers in an unfamiliar place and force him to make the kind of mistakes that we typically don't see from him.