This loss doesn't mean much because the game saw none of the starters get playing time. If the Panthers are hit with a rash of injuries this season, then there will be a reason to be worried. But at the moment, this game shouldn't be viewed as anything more than a final attempt for fringe players to prove that they should make the opening day roster.
With the loss, the Panthers fell to 2-2 in the preseason and now can focus solely on their first regular season game against the Tampa Bay Buccaneeers.
It is safe to say that the Panthers will look like a different team when that game kicks off, as Cam Newton will be back under center and ready to roll.