First, they face the San Francisco 49ers, who went 13-3 last year and were a couple special team blunders away from going to the Super Bowl.
Then, they must prepare for the division rival Chicago Bears in a shortened week, as they play their first Thursday night game of the year.
And finally, Green Bay will host the New Orleans Saints, who nearly beat the Packers in the season opener of the 2011 season in a shootout.
If the Packers are not ready for this death row of games, their record will surely suffer early on, and they will be forced to play catch up the remainder of the year.
I believe Mike McCarthy will indeed make sure his team is ready to face each and every team the Pack face this year, but there will still always be questions surrounding any team.
The following list is of the five biggest concerns Packer fans should have as Green Bay begins their tough regular season, in no particular order.
(Note: this was published before the Packers preseason finale vs. the Kansas City Chiefs. All stats credit to espn.com)