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USC QB Matt Barkley's blind side hasn't been this exposed since his freshman year. Cal needs to capitalize on this weakness.
OT Matt Kalil, Barkley's blindside protector, is now gone to the NFL. Kalil gave up zero sacks in 2012 (that's right, none), meaning Aundrey Walker has impossibly big shoes to fill.
Walker is a good talent, but it's still unknown how he'll fare against top DEs.
DEs Mustafa Jalil and Deandre Coleman need to get to Barkley for Cal to have a shot. If Barkley gets time in the pocket he'll go deep to Woods, Lee and the rest all day.
Pressure by Jalil, Coleman and the rest of Cal's pass-rushers are imperative. If Barkley gets time in the pocket the Bears won't have a chance.
However, if Cal can execute on all of these keys to victory, they'll have a decent chance at spoiling USC's championship hopes.