By Monday, the Bills must trim their squad from 90 to 75 players. And with this game serving as a dress rehearsal for the regular season, some players will not get another chance to impress the Bills' coaching staff.
By Friday, the Bills must have their 53 man roster finalized. This last preseason game means so much for so many players NFL dreams, but the reality is they might not play.
With cuts right around the corner, this will be the last home game as a Bill for the majority of the roster. Though the Bills have one more preseason game against the Lions, many personnel decisions will already be made.
And with that, here are five players who will never again represent the Bills franchise in front of a home crowd.