By Monday, the Bills must trim their squad from 90 to 75 players. And with this game serving as a dress rehearsal for the regular season, some players will not get another chance to impress the Bills' coaching staff.
By Friday, the Bills must have their 53 man roster finalized. This last preseason game means so much for so many players NFL dreams, but the reality is they might not play.
With cuts right around the corner, this will be the last home game as a Bill for the majority of the roster. Though the Bills have one more preseason game against the Lions, many personnel decisions will already be made.
And with that, here are five players who will never again represent the Bills franchise in front of a home crowd.
There is simply not a roster spot available for David Clowney, who has done little to stand out in training camp. If the Bills keep six receivers, the locks are Stevie Johnson, Donald Jones, David Nelson, Derek Hagan and.T.J. Graham.
The No. 6 spot would be between Ruvell Martin, Marcus Easley and Naaman Roosevelt. If they keep seven, Martin is safe and Easley and Roosevelt duke it out.
There is just not a spot for Clowney on the team. He doesn't stick out on special teams, something Martin excels in, and hasn't elevated his game thus far. Even if Clowney steps up and plays great, it is very hard to see him surpassing any of the eight receivers listed and sneaking onto the squad.
Dorin Dickerson was a very interesting prospect for the Bills, but he just doesn't have a spot on the roster.
He is versatile, but has no chance to beat out Corey McIntyre for the fullback spot. At tight end, Scott Chandler and Lee Smith are locks to make the team.
Mike Caussin is on the PUP list but has impressed the coaching staff. If the Bills only go with Chandler and Smith for the time being, there will be plenty of veterans available after cutdown days.
Dickerson is simply the odd man out. He is a decent player and has excited the coaches and fans. But Dickerson is lost in the depth chart and may become another casualty of cut day.
If he doesn't make the team, which is a very realistic possibility, he could land on the practice squad. But Dickerson is just running out of time to impress, cutting down his days as a Bill.
The battle for the No. 2 quarterback spot in Buffalo appears to be over. If Vince Young can put an explanation point on the job with a strong performance against Pittsburgh, Tyler Thigpen is done as a Bill.
Thigpen is simply too inconsistent of a passer to land the gig. Young has really picked up his game and is athletic enough to provide Buffalo another element at the position. With Brad Smith as the No. 3 quarterback, Thigpen appears to be the odd man out.
He had the advantage over Young as Young appeared lost in the playbook early on. But as the weeks went on, Young stepped up and Thigpen regressed.
Unless Young completely unravels, the job is his. Thigpen has looked dull and unimpressive and has lost his grip on the job.
Danny Batten impressed coaches last season and even started some games at linebacker. But 2012 is a different story and Batten looks to be on his way out of town.
The veteran locks at linebacker are Nick Barnett, Kelvin Sheppard, Arthur Moats, Kirk Morrison and Bryan Scott. The two rookies, Nigel Bradham and Tank Carder, should be safe to make the team as well.
This leaves the last linebacker spot a two-way battle between Batten and Scott McKillop.
McKillop is the superior special teams player. In the NFL, no team can ever have enough quality special team players. McKillop has been playing pretty well at linebacker and Batten has been struggling. The special teams advantage puts McKillop over the top and pushes Batten out of a job.
Prince Miller is another player who loses out to the numbers game.
The obvious locks are Stephon Gilmore, Aaron Williams, Jairus Byrd, George Wilson, Da'Norris Searcy and Leodis McKelvin. Terrence McGee, Ron Brooks and Justin Rogers have done enough to make the team and compete for playing time.
Undrafted rookie Delano Howell has really impressed coaches and is quickly moving up the depth chart. This leaves Miller as the odd guy out unless a relatively surprising cut were to be made.