This fight will likely decide who is the greatest light heavyweight in mixed martial arts history. Jones will attempt to successfully defend the championship for the fourth time, and Henderson will try to add one more marquee name to his list of victims.
Henderson comes in on a four-fight win streak that includes a one-off fight at Heavyweight against the legendary Fedor Emelianenko. His knockout power will make him a consistent threat throughout the bout.
The undercard features several well-matched and exciting fights.
Jay Hieron returns to the UFC in the co-main event of the evening as he challenges Jake Ellenberger. The winner of the fight will catapult themselves in to the upper echelon of the welterweight division.
Throughout the evening's action, here are five predictions you can count on for UFC 151.
Takeya Mizugaki and Jeff Hougland will meet on the FX preliminary card.
The bout features two bantamweights trying to get a win after suffering defeat in their last time out. Mizugaki, a former WEC title contender, lost to Chris Cariaso via decision at UFC 144, and Hougland dropped a decision to Yves Jabouin at UFC on Fuel TV: Korean Zombie vs. Poirier.
Hougland is 1-1 in the UFC, but he will be outmatched against Mizugaki. Simply put, Hougland is not a UFC-caliber fighter, and Mizugaki is.
Mizugaki will most likely finish Hougland in a dominant performance. The performance will highlight Hougland's abilities or lack thereof. After tasting defeat for the second straight fight, he will be receive the pink slip from UFC matchmaker Joe Silva.
This should be a good showcase for Mizugaki's skills.
John Lineker entered the UFC on a 13-fight win streak and a lot of buzz. TUF veteran Louis Gaudinot put an end to the hype with a second-round submission win at UFC on FOX: Diaz vs. Miller.
The next opponent for Lineker will not be easy either. Yasuhiro Urushitani will stand opposite him on Sept. 1. Urushitani returns after his TKO loss to Joseph Benavidez back in March.
This should be an excellent fight, and an early contender for Fight of the Night.
Urushitani was leveled by Benavidez, and Lineker will do the same.
Lineker has big power in his hands and will stop Urushitani at UFC 151. He will get his first UFC victory under his belt and begin working his way back up the flyweight ladder.
The fast-paced flyweight battle will open the PPV card.
It has taken nearly seven years, but Jay Hieron will get his third UFC bout.
Unfortunately, he is matched up with one of the top rising prospects in Jake Ellenberger.
Hieron is 16-3 since his last UFC outing. Hieron has excellent striking, but his weakness has been in the wrestling department. That just so happens to be a big advantage for Ellenberger.
As an all-around mixed martial artist, Ellenberger has eclipsed Hieron. His striking improves in every fight, his submissions are ever improving, and just in case things are not going his way, he can always fall back on his wrestling.
The strength of Ellenberger will play a big role in getting Hieron down to the mat. Once there it should be all Ellenberger. The only question remains is will Ellenberger be able to stop Hieron or be forced to grind out a decision?
Hieron is a solid fighter, but Ellenberger will push his UFC record to 0-3.
Several recent UFC PPV's have been criticized for not being as exciting as the earlier preliminary action.
Facebook and FX fights have been more exciting, and included more finishes, than the main card fights. Now, there is nothing the UFC can do about this. Sometimes that is just how a fight pans out. However, at UFC 151 you will have to shell out the $55 to see the most exciting fights of the night.
Preliminary fights such as Daron Cruickshank vs. Henry Martinez and Michael Johnson vs. Danny Castillo will deliver on the free FX portion of the card, but the action starts at 10 p.m. ET.
The very first fight of the PPV looks to be one of the night's best. John Lineker vs Yasuhiro Urushitani opens up the PPV.
Dennis Hallman vs. Thiago Tavares is a fight that has the potential to deliver big with such low expectations. Tavares is consistently one of the most exciting fighters in the UFC, and he should get some respect for delivering.
Dennis Siver vs. Eddie Yagin should be a scrap, and Jay Hieron vs. Jake Ellenberger is an excellent welterweight match-up.
All of this leads to the night's main event between Jon Jones and Dan Henderson. The main card of UFC 151 is well worth your hard-earned money, and will blow the preliminary action out of the water.
Dan Henderson is one of the all-time greats of the sport. Win or lose on Sept. 1. And it will be a loss.
Jon Jones is a special athlete and one of the most dominant champions in MMA history, and he has only been champion for one year. His run through the division has been ultra-impressive. His dominance will continue against Henderson at UFC 151.
Henderson will have a puncher's chance with his KO power, but Jones manages his distance too well to be caught by anything that he will throw.
This will be another jaw-dropping performance by the champion. Jones will make Henderson look his age, and completely take him out of the fight. Nothing Henderson attempts will be able to have any success against Jones.
Jones will continue to look unstoppable, and that's because he is. At least for the time being.