In no season has any team played without their head coach as a result of suspension. In no season has a team gone into June without their future Hall of Fame quarterback signed on the dotted line—which the team is likely headed for (and Brett Favre doesn't count since he wasn't part of the team's plans in any of the seasons you're likely thinking of). And no team has entered a season as vilified and hated as the New Orleans Saints will enter 2012.
Yet no team has ever been better positioned to overcome this kind of controversy and adversity.
The New Orleans Saints could have a magical 2012 season, but it's going to depend largely on the following players. Each of them is going to need to step their game up in 2012 if the Saints are going to do what no other team has ever done.