Although the two teams have enjoyed markedly different fortunes this term and 19 points separate them in the table, both sides have plenty to play for as the season rushes to a close.
Milan currently sit just three points behind league leaders Juventus. They would love nothing more than to close that gap against their local rivals.
Internazionale are 20-plus points out of the title hunt, but they are fighting it out with Udinese and Napoli for the final Champions League place. All three teams are on 55 points with three matches remaining.
The Milan derby is always hard-fought, occasionally ugly and often genius. Here are six bold predictions for Sunday's match.