Chelsea will have a chance to end Barcelona's Champions League defense and avenge their 2009 semifinal loss to the Catalan club on Tuesday when the Blues travel to the Nou Camp for the second leg.
Chelsea will take a 1-0 win at Stamford Bridge into the second leg and could really put Barcelona under pressure if they score first and grab a crucial away goal.
Barcelona will fancy their chances facing just a 1-0 deficit and having the luxury of playing at home, where they are a very difficult club to beat.
However, the last three meetings between these clubs at the Nou Camp have ended in a draw, and if that happens again, Chelsea will advance.
Chelsea will have to defend to perfection on Tuesday if they want a positive second-leg result that sends them to Munich for the Champions League final in May.
Let's look at everything you need to know so you don't miss a minute of the intense action from the Nou Camp.
Where: Nou Camp, Barcelona, Spain
When: Tuesday, April 24, at 2:45 p.m. ET
Watch: Fox Soccer, Sky Sports HD2
Live Stream: UEFA Match Centre
Barcelona player to watch: Lionel Messi
Messi has never scored against Chelsea and will have to break that slump on Tuesday if Barcelona are to advance to their third Champions League final in four years.
Messi needs to use his speed and dribbling skills to cause problems for a Chelsea defense that has looked very shaky at times this season, even to middle- and bottom-tier Premier League clubs.
If Barca are to be successful in the second leg, Messi will have to lead the attack.
Chelsea player to watch: John Terry
Terry desperately wants to get back to the Champions League final and win the competition after his penalty kick miss in the 2008 final could have won Chelsea the European crown.
Terry is a fierce leader and a spectacular one-on-one defender who needs to make sure his back four is focused and ready to face a determined Barcelona attack.
Expect Terry to lead an inspired Chelsea defense in the second leg at the Nou Camp.