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Every time these two sides have come together, it has turned out to be an explosive contest, with first-leg results not giving either manager much comfort, irrespective of the scoreline.
Going into this tie, Chelsea are being labelled the underdogs. This could very well help ease pressure on the players, who otherwise are always carrying the burden of being expected to win the Champions League.
Although Chelsea face the second leg away, they could hold an advantage when it comes to knowing exactly what they need to do in order to make an appearance in Munich.
Considering the magnificence of Barcelona, is it safe to say that Chelsea are in over their heads? Or can England's only representative in the Champions League this season shock the entire football world?
Perhaps they snatch a late winner and break Barcelona hearts to avenge that unforgettable night at Stamford Bridge on May 6, 2009.
One thing for certain is that anything can happen in a cup tie.