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All of the aforementioned No. 2-seed-over-No. 15-seed upsets were huge—but none were as big as Lehigh's beat down of the Blue Devils, 75-70.
You would think that a team like Lehigh would have to play a near-perfect game to take down a team like Duke.
Lehigh was out-rebounded 37-34 for the game, only shot 38 percent for the first half and was down by two at intermission.
Duke, for no apparent reason, over-relied on shooting from beyond the arc, hitting only 6-for-26 three-point attempts.
C.J. McCollum, the two-time Patriot League player of the year and the nation's fifth-leading scorer, was brilliant for the Mountain Hawks, scoring 30 points.
This year's Blue Devils were not, by far, one of the better teams in school history.
But this is still Duke, and their long-standing success and multiple national championships pushes this upset to the top of this list.