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An event this big could feature multiple title fights.
If it were ever possible, maybe the whole main card could be title fights.
But considering they could go 25 minutes a piece, and that a main card of this caliber may already feature five or more other fights, just having the best possible title fight available would work.
The fight would have to feature two of the biggest names in the sport.
It would have to feature two fighters who can put on an exciting fight as well as be able to tell a story both inside and out of the Octagon.
A fight like Jon Jones vs. Rashad Evans or Anderson Silva vs. Chael Sonnen or even Georges St-Pierre would have to be the kind of fight that headlines this event.
One title fight, with a sudden-death round in case of a draw, could work best.