Anthony was injured early in the third quarter when Pacers center Jeff Foster swatted at the ball, catching part of Anthony's hand.
Anthony continued to play despite numbness in the hand, scoring 21 points before leaving late in the fourth quarter of a 135-115 win.
The Denver Nuggets are off to the best start in franchise history at 24-12, and in the middle of a franchise-record seven-game home stand. The Nuggets hold a two-game lead over the Portland Trailblazers and a two-and-a-half game lead over the Utah Jazz in the Western Conference's Northwest Division.
Chauncey Billups has brought much-needed veteran leadership to Denver, and hopefully it will be enough to keep the Nuggets performing at a high level while Anthony is sidelined. Expect Denver swingman Renaldo Balkman to see more of the court in Melo’s absence.