After stumbling into the labyrinthine maze that UEFA call the Europa League, City are the odds-on favourite to go on and win it.
Rivals' United succumbed to the same fate, failing to qualify for the Champions League knockout rounds and now have to face teams that the Manchester giants are more used to meeting in preseason friendlies.
They may be overwhelming favourites, but City will first have to overcome Portuguese giants FC Porto, the reigning Europa League champions.
The tie should be fairly routine for the free-spending Citizens, but Porto could throw a spanner or two in the works if Mancini's men aren't 100 percent on their game.
Here are 10 predictions for the first leg in Porto.