They may find a way to eventually replace his production, but they won't replace his leadership.
The Billups injury is just another chapter in the Clippers' curse.
Here's a quick look at the biggest curses in Clippers history.
Who could forget Manning in 1988.
After capturing a national championship at Kansas, Manning was the No. 1 overall pick in the 1988 NBA draft, but the Clippers curse got him after only 26 games.
A torn ACL later and Manning was never the same.
He carved out a decent NBA career, but you never know what could have been.
Cummings was the No. 2 overall pick in 1982, but was diagnosed with heart arrhythmia, a potentially fatal disease.
Cummings survived his tenure with the Clippers and even won the Rookie of the Year during the 1982-83 season, but he failed to become a major NBA star. His numbers were never better than the 23.7 points and 10.4 rebounds he averaged in his rookie season.
Some of these curses are bad personnel moves, but there are way too many of them in Clippers history to document, but a few of them stand out more than others.
In 1985, with the No. 3 overall pick and the likes of Chris Mullin, Detlef Schrempf, Charles Oakley, Karl Malone, A.C Green and Joe Dumars all available, the Clippers selected Benoit Benjamin, who turned out to be a big bust.
The Clippers (then Buffalo Braves) thought they made a great move in acquiring Archibald for a pair of first-round picks.
Unfortunately, he tore an Achilles tendon before the 1977-78 season and never played a game in a Braves uniform.
Even current superstar Griffin wasn't totally exempt from the Clippers' curse as he missed his entire first season in the league with a knee injury after being selected No. 1 overall.
Billups is the latest victim, as he saw his first season in a Clippers uniform come to an abrupt end with an Achilles injury.
The Clippers were playing very well and now they will have to try and get by without him.
After getting traded to the Clippers in 1983 (for the draft rights to Byron Scott), former Lakers star Norm Nixon had a couple of productive years with the Clippers. He led the league in assists and made the All-Star team during the 1984-85 season.
Then he blew out his knee during a softball game, then ruptured his Achilles tendon a little more than a year later. He missed more than two entire seasons for the Clips.
The Clippers paid a big price for Walton in 1979, giving up forward Kermit Washington, center Kevin Kunnert, a first-round draft pick and $350,000 to get him.
Walton signed a then-record seven-year, $7 million contract to play with the Clippers, but refractured a bone in his foot the fourth exhibition game of the 1979-80 season and played only 14 regular-season contests, averaging 13.9 points.
They were the last games he would play for more than two seasons.