The main event overlooking the face-off between the two fierce rivals on Sunday will not occur as Chelsea captain John Terry will miss the match due to injury. United captain Rio Ferdinand had questions regarding the customary handshake against the man blamed for racially abusing his younger brother. But there is no chance of something like that happening now with Villas-Boas ruling out his captain for the fixture.
Chelsea shall arrive at United with the prospect of missing out on Champions League qualification next season. This season has seen the Blues' fall to lows previously unseen in the Abramovich era. The match against United could well make or break their season though, with Terry, Lampard and Ashley Cole out they are facing a very tough fixture.
On the other hand, United have not been convincing this season but they have managed to be in the title race so far. Anything other than a win against Chelsea could see them falling behind their cross-town rivals City. Sir Alex has been handed a welcome boost ahead of the match with Rooney and Nani declared fit to play.
In the following slides we shall take a look into the few things we can expect at Stamford Bridge when the two English heavyweight clubs face-off with each other.