The injury bug is hovering over Pittsburgh and doesn't seem to want to go away.
Pouncey and running back Rashard Mendenhall are out.
It's likely that they will all play, but that's a lot of stars that won't be 100 percent with the season on the line.
Luckily for Pittsburgh, they have the easiest matchup the playoffs have to offer this season.
Tim Tebow and the Denver Broncos limped into the playoffs, dropping their final three games of the season.
Who will win this Wild Card matchup?
The Denver defense has struggled with consistency, and teams have figured out how to shut down Tebow on offense.
The injuries won't be enough for Tebow to pull off another miracle.
This Steelers' aggressive defense may be wounded, but they are still going to completely shut down the Denver offensive attack.
Offensively, Pittsburgh will be able to manage.
Doug Legursky is expected to move over from guard to play center for Pouncey. Chris Kemoeatu will take over at guard.
It's the same look the Steelers had in last year's Super Bowl.
The team did just fine in the middle of the line in that game, shutting down a forceful B.J. Raji.
Mendenhall won't be greatly missed either. The majority of the Pittsburgh offense has come from Roethlisberger and the passing game this season.
All they should need to win this game is two touchdowns, but they will likely manage plenty more than that.
Even with the injuries, the Steelers will walk away with a convincing victory.