A clash of cultures, style and tradition, bringing together the nouveau riche with the archaic superpower; on January 8, red and blue will collide once more.
After City’s 6-1 demolition of United at the end of October, coupled with their humiliating exit from the Champions League, Sir Alex Ferguson’s side come into the match with something to prove.
After a blistering start to the season spawned an aura of semi-invincibility about both sides, recent tough patches have shown both to be fallible.
It promises to be, therefore, a season-defining game upon which the tides of Manchester will turn.
Here are 10 predictions for the matchup.