Obviously, in any given week of college football, the same number of teams are going to lose as will win. But which teams are going to fall hard? Who will be this week's Notre Dame?
These five, though they all think they can win, are going to endure tough defeats this weekend. Whether it be a blowout or a season-crushing loss, each of these teams (and their fans) will be feeling rough when they wake up on Sunday.
Don't say I didn't warn you.
In a rematch of last year's Valero Alamo Bowl, the Arizona Wildcats visit the Oklahoma State Cowboys. Last year's game was ugly, and with home-field advantage added for the Cowboys, there's no reason to think this one won't be even worse.
The 2010 edition saw Cowboys quarterback Brandon Weeden throw for 240 yards and two touchdowns, with Justin Blackmon notching 117 receiving yards and both of those touchdowns. Wildcats quarterback Nick Foles had a rough night, throwing three interceptions.
Foles had a phenomenal game against the Northern Arizona Lumberjacks (412 yards and five touchdowns) last week, and he has had a good career overall, so it seems like Arizona could have a chance in this game.
But with the game in Stillwater, I think the high-powered Oklahoma State offense will put the Wildcats away early.
The Penn State Nittany Lions were abused last season by the Alabama Crimson Tide, with Nick Saban's crew keeping the Nittany Lions scoreless for three quarters en route to an easy 24-3 win.
This year's rematch could go the same way. After obliterating the Michigan State Spartans in the Capital One Bowl, the Crimson Tide are considered by some to be the best team in the nation.
In their opening game, Alabama's defense held the Kent State Golden Flashes to just 90 yards of offense (and made their nickname seem ironic). Meanwhile, Penn State is shuffling between quarterbacks Matt McGloin and Rob Bolden.
A very good offense is needed to defeat the Crimson Tide, and Penn State simply doesn't have one. Joe Paterno might want to stay in the box again this Saturday. Someone could put on highlights of the 1986 Alabama-Penn State game for him.
Momentum is huge in college football, and these two teams are trending in opposite directions after last week.
While the South Carolina Gamecocks are exhilarated from their comeback win over the East Carolina Pirates, the Georgia Bulldogs are still reeling from their spanking at the hands of Kellen Moore and the Boise State Broncos.
Last season, the Gamecocks contributed to Georgia's early downward spiral with a 17-6 victory in which they outgained the Bulldogs by over 100 yards. (Granted, that was a home game.)
With the schizophrenia of South Carolina, it's impossible to guess how they'll play. But Stephen Garcia showed serious poise and leadership last week coming off the bench and bringing his team from behind, so I think the Gamecocks will be ready, and Mark Richt's head will be on the chopping block at 0-2.
This looked like the year that the Duke Blue Devils might finally return to bowl contention, and then a Week 1 loss to the FCS Richmond Spiders reminded everyone why the Google search "Duke football" prompts a "Did you mean Duke basketball?" reply.
The game against the Stanford Cardinal this Saturday is in Durham, but that doesn't make much of a difference, as Duke has no home-field advantage to speak of in football.
The Alabama Crimson Tide came into Wallace Wade Stadium last year and waxed the Blue Devils 62-13. I expect a similar result and Heisman resume-boosting numbers for Andrew Luck this weekend.
This is the game where the unraveling of the defending BCS champion Auburn Tigers begins. Never was a national champion so reliant on one player. With Cam Newton (and Nick Fairley for that matter) gone, the Tigers should be about where they were before he got there: mediocre.
The Mississippi State Bulldogs, on the other hand, are coming off a solid 9-4 season and a throttling of the Michigan Wolverines in the Gator Bowl.
While the Bulldogs started their season last week with a domination of the Memphis Tigers, Auburn needed a miracle to defeat a Utah State Aggies team that hasn't been to a bowl since 1997.
With 14 returning starters from last season, Chris Relf and and the experienced Mississippi State Bulldogs should handle the Auburn Tigers easily on Saturday.