The Michigan Wolverines have had Notre Dame's number the past two seasons, defeating the Irish in both games.
However, Rich Rodriguez was fired and replaced by former San Diego State head coach and Michigan assistant Brady Hoke.
Hoke brings a straight ahead, pro-style attack with him to Ann Arbor. The question that needs to be asked is whether or not the offensive personnel, especially quarterback Denard Robinson, will be effective in the scheme.
That may not be the biggest issue facing the Wolverines.
The defense was an atrocious unit under Rich Rodriguez in the old 3-3-5 scheme. Brady Hoke has scrapped that in favor of a 4-3 front that he hopes will help improve the defense.
Those question marks may not be solved in time for the match-up with the Irish on Sept. 10 in the Big House.
However, it will be the first night game in Michigan Football history, and ESPN's College GameDay crew will be on hand.
Will those two factors play in Michigan's favor?