This game is not without worry, though. Wyoming has a high-octane offense that they have taken to a resounding 3-0 start.
The Cowboys have not faced nowhere near the competition of Nebraska, but the Huskers are not without their deficiencies on defense.
By large, Nebraska will give up points, but not nearly enough to put a real scare in them as they look to next week's showdown with Wisconsin.
Let's delve deeper into this Saturday's game of undefeated teams.
Where: War Memorial Stadium (Laramie, Wyo.)
When: Saturday, Sept. 24 at 7:30 p.m. EDT
Watch: Versus Network
Listen: Live streaming audio available for $7.95 here, KFBC 1240 AM in Cheyenne, Wyo.; KLIN 1400 AM in Lincoln, Neb.
Betting Line (Courtesy of Betonline.com):
Spread: Nebraska -23
Key Storyline: There is no way to not see the elephant in the room.
Nebraska has their targets set on Wyoming, but every college football fan wants to fast forward to next week when the Huskers take on No. 6 Wisconsin.
Will Nebraska's Defense See Them Out of Top 10 in next 2 weeks?
Bo Pelini better have his players focused on this Saturday, as Wyoming has a dangerous offense.
Who Might Not Play For Wyoming: No major injuries at this time.
BCS/Top 25 Poll Implications: An upset would certainly be enjoyed by Cowboys fans, but would not lift Wyoming into the echelon of the Top 25.
The real shame would be seeing the No. 9 Cornhuskers stumbling before next week's marquee matchup. A solid win will keep them in the Top 10—nothing more, nothing less.
What They're Saying:
The LA Times describes the closing seconds of Wyoming's nail-biter last week.
"The Wyoming defense allowed Bowling Green signal-caller Matt Schilz to record the first game of his career with more than 300 yards passing, he finished with 437 yards, the rest of the Cowboys were there to pick up the pieces...specifically as Gabe Knapton and Josh Biezuns blocked the potential game-tying PAT with under three seconds remaining in regulation."
Defensive coordinator Carl Pelini spoke with reporters this week.
"I thought we had a good week of practice so far. Three extremely different offenses, and then a fourth that’s different than anything we’ve faced. Working with young defensive backs with [Alfonzo] Dennard being out, some new guys in different positions, it’s been a nightmare to face four offenses where there is no carryover one bit from week to week."
Wyoming Player To Watch: Brett Smith is the first freshman to start for Wyoming since 1974. He has been wonderful so far, getting the Cowboys to 3-0 behind 797 yards thrown and five touchdowns.
Nebraska Player To Watch: Taylor Martinez has been the impetus for the Huskers' success so far, both rushing and receiving.
He will be as elusive as ever on Saturday, building on 490 yards by air and 384 yards by ground.
Key Matchup: The Huskers' defense is the one thing that will be put to the test on Saturday. Wyoming can score, and Nebraska has proved to be shaky on that side of the ball so far.
This is a team that has given up more than 400 yards the past two games. At some point they are going to have to stop the bleeding if they are to beat top-shelf programs.
On the Hot Seat: Both coaches are safe at the moment, although a loss of this magnitude would put the wrong kind of spotlight on Bo Pelini.
Prediction: Nebraska 42, Wyoming 24