The Big Ten is the Big Ten in name only (12 teams), the Pac-10 is the Pac-12 and Texas A&M is rumored to be heading southeast.
Despite all of the shuffling that's already occurred, conference realignment is likely just getting started.
Here are five matchups that will now happen or are likely to happen in the years ahead.
In just two weeks, college football fans will be treated to the first dream contest of the new conference season.
Big Ten newcomer Nebraska heads to Madison to face the Badgers in what is likely to be a matchup between two undefeated, top 10 teams.
Both squads are synonymous with power football, and they will be battling each other for Big Ten titles for years to come.
Utah might be new to the Pac-12, but they aren't new to success.
The Utes have spent the last decade or so relishing the role of giant-killer, and now they get the chance to do it week in and week out.
Lane Kiffin hopes to return USC to glory, and if he does, college football fans should circle this matchup on their calendar every year.
With the current college football landscape the way it is, you have to believe it's only a matter of time before Notre Dame joins the ranks of conference play.
The Big Ten has been after the Irish for years, and it's a natural fit.
Traditionalists nationwide are licking their chops at the prospect of the Beavers and the Irish meeting every season.
If the SEC continues to expand, South Florida is a natural target.
The Bulls are an up-and-coming team that have been on cusp of powerhouse status for a few seasons now, and this is one of the few moves that makes sense geographically.
The battles on the field and on the recruiting trail between USF and the Gators would be remarkable.
Assuming the Sooners head west and not east, it's hard to imagine a more compelling yearly matchup than one between Oklahoma and USC.
The Sooners and Trojans have long been a part of college football royalty, and fans would relish the opportunity to see them line up against one another year after year.