The Alabama Crimson Tide reclaimed the title of being the program ranked below the Oklahoma Sooners, capturing a 27-11 win over the Penn State Nittany Lions as 10-point road favorites Saturday.
LSU dropped a notched after posting a 49-3 win over non-FBS opponent Northwestern State, failing to cover as 49-point home favorites.
The Tigers have an opportunity of leap-frogging the Crimson Tide again if they are able to pull off a road win in their SEC-opener Thursday night against the No. 25 Mississippi State Bulldogs.
Let's take a closer look at the upcoming week from a betting perspective.
The LSU Tigers (2-0) moved up to No. 2 in the AP poll after their 40-27 neutral site win over the Oregon Ducks at Cowboys Stadium in Week 1, but have dropped down in this week's edition due to playing a non-FBS opponent.
Mississippi State (1-1) was unable to start the year with a 2-0 record, dropping a 41-34 contest against the Auburn Tigers as 5.5-point road favorites.
Tigers head coach Les Miles is likely to come away with a spread victory, as the program is 7-1 ATS in its last eight trips to Starkville.
The No. 4 Boise State Broncos (1-0) enjoyed their 35-21 neutral site victory over the Georgia Bulldogs with a week off and now return to action versus the Toledo Rockets (1-1).
It will be interesting to see if the Rockets will rebound from a near-miss, dropping a 27-22 road game to the Ohio State Buckeyes as 18-point underdogs.
Boise came away with a 57-14 win in last year's meeting on the blue carpet, easily covering the 38-point spread.
The Maryland Terrapins (1-0) will play their second consecutive opponent at home to open the season, hosting No. 18 West Virginia Mountaineers (2-0) to start Saturday's action on ESPNU.
Maryland came away with a 32-24 win on Labor Day over the Miami Hurricanes as four-point favorites.
West Virginia has beaten Norfolk State and Marshall by a combined score of 89-25.
The Mountaineers will be aiming for their sixth straight win in the series, including a 31-17 home win last year as 10-point favorites.
The Auburn Tigers (2-0) have withstood two close games in the opening weeks, picking up home victories over Mississippi State (41-34) and Utah State (42-38).
Life without Cam Newton will now take to the road for the first time, and this week's opponent will be out for revenge.
Clemson (2-0) will be playing its third consecutive home game and will be looking to win this year's series meeting after falling 27-24 on the road as 7.5-point underdogs in 2010.
This battle between the Tigers is going to be one to watch.
The No. 10 Nebraska Cornhuskers (2-0) survived a scare in this week's 42-29 win over the Fresno State Bulldogs as 28-point home favorites. It's a contest where the team was actually out-gained by six yards.
Washington (2-0) held on to a 40-32 win over Hawaii and will be looking to make it two in a row in this series.
The Huskies shocked the Huskers as 11.5-point underdogs a year ago in the Holiday Bowl, coming away with a 19-7 win.
The Notre Dame Fighting Irish (0-2) will need to emotionally recover from a game that they seemingly controlled three different times, falling 35-31 to the Michigan Wolverines in Ann Arbor.
Michigan State (2-0) has had no problems taking care of lesser opponents to start the year, posting 44-0 and 28-6 victories over Florida Atlantic and Youngstown State, respectively.
Bettors will likely jump on the Spartans due to their 7-0 ATS mark in the series.
The Texas Longhorns (2-0) have bounced back from a disappointing 2010 season, winning its first two games over BYU (17-16) and Rice (34-9).
UCLA (1-1) was likely looking ahead to this week's game when finishing off the San Jose Spartans by a 27-17 margin at the Rose Bowl.
The Bruins have also won the last three meetings between these two schools.
The Ohio State Buckeyes (2-0) head to South Beach after two home wins over Toledo (27-22) and Akron (42-0).
Media coverage this week will likely focus on off-the-field issues for both schools, which will likely land the two storied programs in the NCAA's doghouse starting in 2012.
The Miami Hurricanes (0-1) will have nearly two weeks to prepare for this contest after dropping a Labor Day contest against the Maryland Terrapins.
Bettors will find that the Buckeyes have covered the last two meetings, including last year's 36-24 win inside Ohio Stadium.
*The line for this contest has yet to be released.
The Oklahoma Sooners (1-0) and Florida State Seminoles (2-0) will meet in the most anticipated game of the week.
Last year's meeting was a disappointment for fans of both schools wanting a close game, as Oklahoma registered a 47-17 blowout win over Florida State as seven-point home favorites.
Oklahoma also won its last National Championship at the expense of the boys from Tallahassee, picking up a 13-2 win on Jan. 3, 2001.
The Tomahawk Chop will get prime-time coverage Saturday night.