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Is it bad to lose to a Top-Five team in the first week of the season? No. Did it potentially ruin Oregon's BCS Championship hopes before Labor Day? Yes.
The Oregon Ducks had four turnovers in a big-time game against LSU, and that was too much to overcome, losing 40-27. The offense looked slower than usual, and their special teams made too many mistakes without Cliff Harris. All of this is not as important as the simple fact that they now have a loss.
In this era of the BCS, one loss can be enough to prevent a team from competing for a national championship. Just as importantly, the fact that Oregon lost to an SEC team could be enough to stop them from making it as a one-loss team.
If a spot in the championship comes down to Oregon versus LSU or any SEC team that obviously finished better than the Tigers, it would be tough to justify putting the Ducks ahead of anyone.
Each of these teams had a lot of guts in scheduling this game in Week 1. However, Oregon might not be able to come back from this devastating defeat.