For the third time in four years, the Irish will start their season against a team they've never faced before in the school's storied history. Notre Dame defeated San Diego State in 2008 and Nevada in 2009, and this year the Bulls of South Florida will invade South Bend for the season opener.
The game will feature two head coaches trying to launch the second season with their respective teams on the right foot. With the Bulls considered a contender for the Big East conference title and Notre Dame starting the season ranked No. 16, the stakes will be relatively high for both sides.
To break down this unfamiliar face, here are the top 10 things to know about South Florida before Saturday's kickoff.