Penn State owns a 6-1 advantage over Northwestern at Beaver Stadium with its lone loss coming in 2004.
The Nittany Lions best home win, however, came last season when Joe Paterno picked up his 400th career victory in a mammoth comeback.
Trailing 21-0, former walk-on Matt McGloin completed a 7-yard touchdown pass to Brett Brackett with :03 left in the first half. That touchdown sparked a rally and a near flawless second half performance.
Penn State scored three third quarter touchdowns as the Lions prevailed in a historic 35-21 win for Paterno's milestone victory.
Best Game - 2005 (Penn State 34 Northwestern 29)
In an extremely difficult call, the 2005 game barely gets the nod over the 2010 comeback.
The 2005 classic gets the edge due to the dramatics of the game. Penn State headed into the season with high hopes behind Michael Robinson, Deon Butler and Derrick Williams, but the season could have taken a turn for the worse with a loss at Northwestern.
Staring at a fourth-and-15 at its own 15-yard line, Robinson fired a laser to tight end Isaac Smolko to move the chains. Moments later, Robinson absorbed a crushing hit and lofted a 36-yard game-winning touchdown pass to Williams, who ducked through a tackle for the score with less than a minute to play.