Without Matt Barkley, the Trojans don't stand a chance.
We were all witness to the collapse of the 2012 college football season last weekend, as Kansas State and Oregon both lost games to give the SEC another shot at a national title.
Week 13 will be just as crucial for teams, and injuries could play a big part in deciding who falls where in bowl games and conference standings.
The biggest injury this weekend is Matt Barkley for USC. It's a crying shame that he has to miss this game. The Trojans don't stand a chance against Notre Dame's vaunted defense without him, and Notre Dame will coast into the national title game.
There aren't any significant injuries for Georgia or Alabama for rivalry week. Both teams will play their instate rivals, and both teams look to be the better teams on paper.
Running backs T.J Yeldon and Eddie Lacy are both probably for the Crimson Tide, while wide receiver Kevin Norwood remains questionable with an undisclosed injury.
Alabama shouldn't have any problem dispatching a woeful Auburn side this weekend, so Nick Saban might even elect to give some starters a break if the game turns into a blowout.
Safety Bacarri Rambo is probably for Georgia, while fullback Merritt Hall and guard Chris Burnette remain questionable.
Kickers David Scully and Justin Moore are questionable for Georgia Tech, as are offensive lineman Will Jackson and Errin Joe. Both linemen have missed the last four games, but remain questionable for rivalry week.
Another big rivalry matchup will be Oregon vs. Oregon State.
Oregon is coming off a heartbreaking loss at home to Stanford, and will look to exact revenge on their instate rivals.
Oregon State's task will be a bit more difficult as starting quarterback Cody Vaz looks doubtful for the matchup.
Vaz, who won the job earlier in the season, missed lat weeks game against California, and is likely to miss this weeks rivalry game.
In the Florida State - Florida matchup, both quarterbacks are probable to play with ankle injuries sustained last weekend.
Jeff Driskel and E.J. Manuel are both likely to suit up. It'll be interesting to see how their mobility will be limited during the match.