Not again.

South Carolina running back Marcus Lattimore exited the Gamecocks’ matchup with Tennessee earlier today after taking a hit to his right leg late in the second quarter.

This injury comes after Lattimore suffered a left knee injury last season and missed the team's six remaining games.  The injury required an offseason’s worth of rehab in order to return in time for the start of the 2012 season.

Lattimore, a junior, has racked up 2,599 career rushing yards for a 92.8 yards per game average while with South Carolina, and has 37 total rushing touchdowns.

Due to his status as one of the best running backs in college football, Lattimore’s injury has led to widespread reaction throughout the nation.

Here are tweets from fellow NCAA players and coaches, and players across the NFL, offering their support for the Gamecocks’ star.

 

LSU punter Brad Wing:


Aggies' freshman quarterback Johnny Manziel:

 

Oklahoma junior wide receiver Kenny Stills:

 

Kentucky Wildcats' quarterback Maxwell Smith:

 

Alabama freshman running back Kenyan Drake:

 

Missouri back Henry Josey:

 

Cleveland Browns' quarterback and former Oklahoma State passer Brandon Weeden:

 

Last year's Heisman Trophy winner and current Washington Redskins' star Robert Griffin III:

 

Former Georgia Bulldog and current Philadelphia Eagle Brandon Boykin:

 

Dallas Cowboy and former Oklahoma Sooner DeMarco Murray:

 

Pittsburgh Steeler and former Georgia Tech back Jonathan Dwyer:

 

Wade Smith and Andre Johnson of the Houston Texans:

 

Jacksonville Jaguars' receiver Cecil Shorts III:

 

San Diego Chargers' wide receiver Eddie Royal:

 

Lance Briggs of the Chicago Bears:

 

Brian Bostick of Newberry College and the Green Bay Packers:

 

LSU head coach Les Miles: