After a week in which two top-10 teams in USC and Michigan State went down, Week 4 promises to feature some more low moments for several Top 25 programs.
From the ACC to the Big 12, top squads will fall as the BCS picture begins to sort itself out in late September.
Let's take a look at three Top 25 teams set to fall this weekend.
No. 10 Clemson
The Tigers have been explosive offensively thus far in 2012, but they will meet their match this Saturday night on the road against the No. 4-ranked Seminoles of Florida State.
FSU has allowed just three points in three games this season and shut out its last two opponents, outscoring Savannah State and Wake Forest 107-0 over the past two weeks.
With E.J. Manuel and Chris Thompson providing an offensive spark for the Seminoles, Clemson will need a flawless performance on both sides of the ball at Doak Campbell Stadium in order to remain undefeated after Week 4.
Although they are one of the ACC's finest programs, they aren't in Florida State's league defensively.
No. 11 Notre Dame
Which team has the best shot to survive in Week 4?
The Fighting Irish coming into Week 4 ranked No. 11 is surprising to say the least, but the wild ride Notre Dame is on will soon come to an end this weekend when it plays host to No. 18 Michigan in South Bend.
Unlike Michigan State, the Wolverines boast a potent offensive attack led by a legitimate Heisman Trophy candidate in senior quarterback Denard Robinson.
Michigan has beaten Notre Dame three straight times and will be playing with less to lose as a one-loss team. Look for the pressure of staying undefeated to finally get to Everett Golson and the Irish this weekend.
No. 15 Kansas State
Despite a hot start to the 2012 season, the Kansas State Wildcats will find themselves in too deep on Saturday night in Norman when they take on the No. 5-ranked Oklahoma Sooners.
Oklahoma dismantled the Wildcats in Manhattan last season, winning 58-17. And the Sooners are led by quarterback Landry Jones and running back Damien Williams, who is averaging 13 yards per carry through two games this fall.
Week 4 also signals Kansas State's first road game of the season, which will certainly add to their problems as they get set to take on a BCS favorite in hostile territory.
2012 NCAA Football Rankings: Week 4
*All Information Courtesy of ESPN.com.
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