Dwyane Wade had 33 points, 10 rebounds, nine assists, and three steals to lead Miami past San Antonio 99-83.
Tim Duncan scored 22 points and captured 11 rebounds for the Spurs who lost Tony Parker for the game in the first quarter and learned they will be without the All-Star guard for two weeks because of an ankle injury.
The Heat unleashed an 18-0 run that ultimately secured their victory and escalated their early attainable lead to a 24-12 showing at the end of the first.
Micheal Beasley and Dwyane Wade had eight points a piece in the 1st, and Wade also pitched five assists.
San Antonio's 12 points was the lowest point total of any quarter this season for the winless Spurs.
During the tear, the Spurs went scoreless for 5:00 and witnessed star point guard Tony Parker injure himself.
After coming off an Oberto screen, Parker drove to the basket and contused his ankle and crumbled to the floor. Tony then was accompanied by a trainer who helped him reach the locker room
Miami continued their assault in the 2nd and opened the lead up even further thanks to backup point guard Chris Quinn. Quinn sunk three long distance bombs in the 2nd, accounting for all nine of his points. Wade also knocked down a jumper with six seconds remaining in the half, closing out the first 24 minutes on a good note.
With the basket, Miami led 50-32 heading into halftime.
The Heat dominated every aspect of the game, shooting over 48 percent from the field, 100 percent from the free thrown line, and out dished and rebounded San Antonio in the first half.
Michael Beasley lumbered off towards the locker room late in the 3rd quarter after scoring 10 points in the period. He returned concluded his night with 20 points, seven rebounds, and 10-10 from the free throw line.
The Spurs made it interesting after Ime Udoka's fast break dunk trimmed the lead to nine (89-80) but on the next Heat possession, Wade slithered through the paint and kicked the ball out to an open Daeqaun Cook who nailed a three pointer, making the score 92-80.
The Heat had previously lost 10 straight road games in San Antonio before the win.