The Clippers held a 56-33 advantage on the boards, having three players with at least nine rebounds.
They also shot 51 percent, compared to just 40 percent for the Wolves.
They led 68-58 at half, and kept Minnesota to just 32 points in the second half, including a paltry 11 in the fourth quarter.
Blake Griffin and Ryan Gomes had 22 points and 10 rebounds apiece for Los Angeles, and DeAndre Jordan chipped in nine points and nine rebounds.
For Gomes, it was the second time he faced the team he played with from 2007-10, where he was a regular starter in Minneapolis. The Clips improved to 1-1 in those contests.
Michael Beasley had 20 points and Kevin Love added 12 points and 10 rebounds for his 15th consecutive double-double, a streak that dates back to November 19th, when he went scoreless in 34 minutes in a 112-95 loss to the Lakers.
It was a sub-par day for the 6'10" Love, who had possibly the best game on his three-year career on Saturday—a 43-point, 17-rebound contest that saw the Wolves narrowly lose 115-113 in Denver.
"We didn't execute our game plan on the defensive end by any means, and the same thing on the offensive end. This isn't how you want to end a road trip." Love said, ending the Western trip with an 0-6 record.
Martell Webster is becoming a key contributor in the Wolves' offense, scoring 18 points in 34 minutes. Luke Ridnour was the fourth leading scorer, surpassing 10 in the points column, putting up the exact number in 25 minutes.
It moved the Wolves to 6-23, and an awful 1-17 record away from the friendly confines of the Target Center, where they have done significantly better with a 5-6 record.
They are now 14 games behind the first-place Utah Jazz and have won just two out of their last 15 games.
The Clippers move to 8-21 with the victory. They are on a three-game winning streak and host the 13-15 Houston Rockets on Wednesday at the Staples Center.
The Timberwolves are happy this road trip is over, and although they accomplished next to nothing on it, it means they can return to Minneapolis once more, where Al Jefferson returns Wednesday night for the 20-9 Jazz.