Week 10 is highlighted by three NFC showdowns. The Falcons take on the Saints for first place in the NFC South in an early start.
The late games feature the Lions vs. the Bears and a game between the 49ers and Giants that could end up deciding who gets the No. 2 seed in the NFC behind the Packers.
Click through to see a prediction for each Week 10 game.
This is the perfect bounce back game for Philip Rivers. He is facing an Oakland defense that is 27th in total defense and 20th against the pass. A strong performance in this one could put to rest the questions about Rivers and his health.
For the Raiders to win this game, they are going to have to control the clock. That will be an easier task if Darren McFadden is able to play this week. Michael Bush is a good running back, but McFadden gives the Raiders that big play potential.
Chargers 24 Raiders 17
The Eagles are clearly the better team in this one. They feature one of the best rushing attacks in the league, and the Cardinals are 16th against the run. Look for a big day from LeSean McCoy.
The best bet the Cardinals have to win this game is controlling the clock. If they are going to do that, Beanie Wells will have to be a lot more effective than he was last week we he ran for 20 yards on 10 carries against the Rams.
Early indications are that Kevin Kolb will miss this game as well. That does not bode well for an Arizona offense that is already struggling.
Eagles 38 Cardinals 17
These two teams are very similar on defense. They both give up about 358 yards per game.
That means the edge goes to the Panthers because they have an offense that is able to take advantage of weak defenses. Cam Newton should be able to run and throw all over the Tennessee defense. Look for a big day from Greg Olsen because the Titans are bad at covering opposing tight ends.
The good news for the Titans is that Chris Johnson looked to have his burst again in the first half of last week's game. With Kenny Britt out for the season, the only shot the Titans have at scoring points is for CJ to be dynamic.
Panthers 27 Titans 17
This should be a really good game.
The biggest problem for the Buccaneers in this game will be slowing down the Houston two-headed rushing-monster of Arian Foster and Ben Tate. They are averaging a combined 171.6 yards per game. The Tampa rushing defense gives up 132.4 yards per game.
The only way the Bucs have a chance to win this game is if Josh Freeman has a big game. That will not be an easy task against the second ranked NFL passing defense.
Texans 24 Buccaneers 17
The Dolphins looked like a dangerous football team on Sunday. Matt Moore was efficient. Reggie Bush was explosive. Can they carry that into this week's game against the Redskins?
As for the Redskins, they are a mess. They have played pretty well on defense, but their offense is really bad. They are 21st in the league in total offense and haven't scored more than 20 points in any game since Week 2.
Dolphins 24 Redskins 13
This will not be a good game to watch because it features two teams that will not combine for 10 wins this season.
Look for Maurice Jones-Drew to have a field day in this one. The Colts are giving up 146.1 yards rushing per game. The Jaguars will be perfectly content to let their rookie quarterback turn around and hand the ball to MJD 30+ times. The Colts will not have an answer.
Jaguars 21 Colts 10
This is an AFC West showdown. If that does not get you excited, I do not know what will.
The biggest factor in this game is how the Chiefs bounce back from being throttled at home by the Dolphins. They are the better team and still have a chance to win the division. Dwayne Bowe should have a big game in this one.
Chiefs 27 Broncos 21
There is going to be a lot of offense in this game. Both teams are in the top twelve in offense.
The edge goes to the Cowboys because they are better on defense. They are 11th in total defense and 10th against the run.
The Bills have come back down to earth a little bit with losses in two of their last three games. This is a tough road trip for them following their loss to the Jets last week. They will have trouble getting Fred Jackson going, and that will lead to a couple of interceptions from Ryan Fitzpatrick.
Cowboys 31 Bills 24
This game is for control of the NFC South. The Saints currently hold a half game lead over the Falcons.
Atlanta will have trouble slowing down Drew Brees and the Saints passing attack. They give up 245.3 yards per game through the air, and the New Orleans offense throws for 319 a game.
The Falcons will try to counter that with a heavy dose of Michael Turner. Shortening the game will be their best plan of attack.
Saints 24 Falcons 21
This might be one of the quickest games in NFL history. Both of these teams are terrible against the run. The Browns are 30th and the Rams are 32nd in rushing yards allowed per game on the season.
The Rams look to have a bit of an edge in this one because Cleveland will once again be without Peyton Hillis and Monterio Hardesty.
St. Louis will just keep handing the ball to Steven Jackson. If the Browns creep up the extra defender, Sam Bradford can throw the ball enough to take advantage.
Rams 17 Browns 13
This is the Bengals chance to prove to the world that they are for real. They are currently sitting at 6-2 in first place in the AFC North.
Andy Dalton has played well, but he has not faced a defense that will be able to give him the different looks the Steelers will. Look for Dalton to struggle in this one.
The Steelers will have their own challenges on offense. The Cincinnati defense has been outstanding so far this season. They are currently 4th in the league in total defense.
Pittsburgh gets the slight edge in this one because they have been in more games like this than the young Bengals.
Steelers 20 Bengals 10
The Ravens should pick up an easy win in this one. There is good chance the Seahawks will not score.
However, the Ravens had a game very similar to this one a few weeks ago against the Jaguars on Monday Night Football. They were clearly the better team on paper but lost the game.
John Harbaugh will not allow his team to have another let down.
Ravens 23 Seahawks 3
This is not a game you would have circled before the season started as one of the best of the year, but it turns out that it is just that. The winner of this game will have the inside track for the No. 2 seed in the NFC.
The 49ers have a huge advantage in this one because of Frank Gore. San Francisco will feed him the ball against the Giants 25th ranked run defense. That will also keep Eli Manning and the New York offense on the sideline.
Eli Manning should be able to move the ball against the 49ers pass defense that is ranked 22nd against the pass, but in the end, they will not be on the field enough to win the game.
49ers 24 Giants 20
The Bears defense is ranked 26th in the league. Look for Matthew Stafford and Calvin Johnson to put up some big numbers in this one.
Matt Forte could also have a big game here. The Detroit defense ranks 28th against the run.
The Lions won the matchup between these two earlier this season on the back of big plays from Johnson and running back Jahvid Best.
We will see a similar storyline in this one. The Lions will win on a late throw from Stafford to Johnson.
Lions 27 Bears 20
The Patriots defense held the Jets offense to just 255 total yards when these two teams met earlier this season. It is very unlikely that the New England defense will be able to play that well this time.
Mark Sanchez will be the deciding factor in this one. A good game from him will be enough to get the Jets a win.
Tom Brady threw for 321 yards in that first meeting. The Jets defense is 7th against the pass, so it is hard to see him throwing for that many yards this time.
A late throw from Sanchez to Holmes will be the difference.
Jets 31 Patriots 27
It is hard to see any scenario where the Vikings can keep this game close. They can feed the ball to Adrian Peterson and hope he can chew up some clock, but in the end, the Packers offense will be too explosive.
The Vikings were ahead 17-13 at halftime the first time these two met, but the Packers scored 20 points in the third quarter to put the game away. Expect something similar this time.
Packers 34 Vikings 20