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Ken Whisenhunt's job is on the line, and he knows it. The Cardinals have a number of spots on their roster that need help, and it's up to Whisenhunt and management to fill them with talent from the draft.
Quarterback: This one is pretty obvious. The Cardinals probably had the worst QB play in the league last year thanks to Derek Anderson, Max Hall and John Skelton. Skelton started late in the season and showed signs, but I don't see him as a starter in this league. A trade for Kevin Kolb has been rumored, but without a new CBA in place that will not happen. The only QB I see worth taking this high (fifth pick) in the draft is Blaine Gabbert out of Missouri. He still needs some work, but could be very good in a couple years.
Outside Linebacker: The pass rush from this spot last season was awful. Clark Haggans and Joey Porter are too old to get the job done in the 3-4 scheme, and youth is needed. There are two players worth taking at this spot. The first is Von Miller out of Texas A&M, who may be the best player in the draft, and next would be Robert Quinn out of North Carolina, who didn't play last season due to suspension.
Offensive Line: Both the guard and tackle spots need help. Part of the reason the QB play was so bad last season was due to the play of the line. They can't pass or run block, and it must be addressed. There is no guard worth taking here, but at the tackle spot Tyron Smith out of USC could be someone the Cardinals look at.
Best bet: Von Miller somehow falls into the Cardinals' lap.
Next best: The Cardinals take Gabbert if he's there or take best available player on the board in Patrick Peterson.