The NFL provided us with some blockbuster Week 6 matchups. I'm going to pick winners against the spread for all the games on the slate.
The New York Giants will be in San Francisco to face the same 49ers team they knocked out of the NFC Championship game last year—the biggest game of the week.
The Green Bay Packers will be in Houston to face the Texans in a must-win game for Aaron Rodgers and his team. If the Packers lose, they'll fall to 2-4 and will have a tough road to the playoffs.
All in all, there are 14 games on the schedule, and as we know, any team can win on any given Sunday.
So, without further ado, here are my picks for Week 6.
Note: All spreads are courtesy of FootballLocks.com.
Prediction: Steelers win and cover the spread.
After a rough game against the Philadelphia Eagles, the Pittsburgh Steelers will find the Tennessee Titans to be much easier to conquer.
The Titans have the No. 27-ranked pass defense in the NFL—and after getting frustrated by the tough secondary of the Eagles—Mike Wallace and Antonio Brown are set to dominate the porous secondary of the Titans.
The Titans are also not stopping the run this year, ranked No. 28 in that category, and Rashard Mendenhall looked fantastic against the Eagles last week.
Furthermore, the Titans are suffering greatly on offense, and even without Troy Polamalu, the Steelers shouldn't have any trouble bottling this team up.
Prediction: Browns win and cover the spread.
Call me crazy if you will, but I'm sensing Brandon Weeden's first career win coming this week against the Cincinnati Bengals.
The Cleveland Browns have shown flashes of competence this year—and even though the Bengals have a better overall team—I predict the Dawg Pound will erupt at the end of this game after Trent Richardson and Weeden lead their team to victory.
This is simply a gut feeling. I don't have any supporting facts with which to make my case.
Prediction: Colts win and cover the spread.
Andrew Luck is legit.
This young quarterback just outplayed Aaron Rodgers in Week 5. I don't see Mark Sanchez and his anemic offense putting up more points than the Indianapolis Colts this week.
The New York Jets' slide to the basement of the NFL will continue in Week 6. The Colts will embarrass this team and win by more than a touchdown.
Prediction: Buccaneers win, but Chiefs cover the spread.
Neither of these teams features a strong offensive attack right now.
Whether it's Cassel or Brady Quinn, the Chiefs are going to struggle, because they'll be operating without the benefit of a strong running game. The Tampa Bay Buccaneers are one of the top run-stuffing teams in the NFL, giving up only 73 yards per game and 3.2 yards per carry.
This game will be close, but in the end, Josh Freeman will do just enough in the passing game to win by a field goal.
Prediction: Falcons win and cover the spread.
I feel bad for the loyal fans of Raider Nation. They're about to have their hopes dashed upon the rocks this week at the Black Hole.
The Oakland Raiders are among the worst teams in the NFL against the pass, allowing 283 yards per game and nine touchdowns through four games.
Without a reliable pass rush, the Raiders porous secondary doesn't stand a chance against the likes of Roddy White, Julio Jones and Tony Gonzalez.
Finally, considering the amazing success the Falcons have had this year on defense, the only logical outcome I can fathom is an absolute bloodbath in favor of the Falcons.
Prediction: Cowboys win and cover the spread.
The Dallas Cowboys have had two weeks to prepare for this game and I fully expect this team to come out with a sense of purpose to erase a miserable Week 4 performance from their minds.
The Baltimore Ravens are highly susceptible to a determined running game, allowing 118 yards per game and six touchdowns through five games. I see DeMarco Murray having a field day against this overrated defense.
Tony Romo will make amends for his five-interception performance of two weeks ago and I see the Cowboys winning by more than a touchdown.
Prediction: Lions win and cover the spread.
This is going to be a close game.
Besides the 27-6 drubbing the Philadelphia Eagles took in Arizona, they've won or lost their four other games in 2012 by one or two points.
The Detroit Lions are 1-3 right now; this team has had two weeks to think about their current situation. There's simply too much talent on both sides of the ball for me to believe this team will fall to 1-4.
If that happens, the Lions 2012 season will be lost. As undisciplined as this team may be, one thing Jim Schwartz has instilled in his players is a fighting spirit.
The Lions will pull this one out by a small margin.
Prediction: Dolphins win, but the Rams will cover the spread.
I'm a huge fan of what Jeff Fisher has done to make this St. Louis Rams team into a contender early this season, but I don't believe they'll come away with the victory this weekend on the road in Miami.
The Dolphins have one of the NFL's top defensive units and Sam Bradford doesn't have any weapons to get the ball to on the outside. Steven Jackson will be gobbled up by the NFL's top run-stuffing defense and the Rams won't be able to generate any offense.
Ryan Tannehill has shown some impressive poise and skill so far this year. He will do just enough to keep the chains moving when Reggie Bush isn't pounding the ball.
Prediction: Patriots win and cover the spread.
The Seattle Seahawks have a championship-caliber defense, but this team hasn't faced an offense like the one the New England Patriots are running these days.
The three-headed monster of Stevan Ridley, Danny Woodhead and Brandon Bolden will prove to be too much for the Seahawks defense to handle—and Tom Brady's one-word, no-huddle offense will confuse this young secondary enough times to force some busted coverage.
The Patriots also feature a terrific young defense; this unit will be in the backfield terrorizing Russell Wilson all game long when it's not stuffing Marshawn Lynch and the Seahawks running game.
Prediction: Cardinals win but the Bills cover the spread.
This game might be too ugly to watch unless you're a devout fan of one of these teams.
The Arizona Cardinals defense will stifle the Buffalo Bills running game. The Bills defense will stifle any running back the Cardinals run with and neither quarterback will have much success.
In the end, I give this game to the Cardinals because I believe Larry Fitzgerald will come through in the clutch for his team and win the game at the end with a touchdown on a jump ball.
Prediction: Redskins win and cover the spread.
The Washington Redskins are optimistic about Robert Griffin III's availability for this game, according to the Los Angeles Times. He's already been cleared to practice and I'll be shocked if he misses a game.
The catalyst for the Redskins' success isn't RG3, though. Alfred Morris is the reason the Redskins will win this game. Morris is already one of the NFL's top running backs. He's going to prove his case even more after running over and through the Minnesota Vikings tough defense.
Christian Ponder threw two picks in last week's game—his first two of the year—and I'm expecting him to throw a couple more against the Redskins this week.
Prediction: 49ers will win and cover the spread.
Alex Smith leads the NFL in passer rating after five weeks; he's going to prove, once and for all, he can compete with any of the elite quarterbacks in the league this week against Eli Manning and the New York Giants.
I expect the San Francisco 49ers to continue rolling on offense, both in the passing game and in the running game. There is too much balance and skill at every position for the Giants to handle. I'm expecting another blowout, though not as big as the past two this team has been a part of.
Prediction: Texans win and cover the spread.
It's going to be a long, long game for Aaron Rodgers.
The Houston Texans feature one of the best front sevens in the NFL and J.J. Watt will be in Rodgers' face all game long.
On the other side of the ball, Arian Foster is going to continue with his monster 2012 campaign and run roughshod all over the Green Bay Packers defense.
I'm not expecting a complete blowout, but I won't be shocked if the Texans win by more than two touchdowns.
Prediction: Chargers win and cover the spread.
For whatever reason, Peyton Manning has struggled throughout his career against the San Diego Chargers. According to ESPN.com's Bill Williamson, Manning has thrown 12 touchdowns and 16 interceptions against the Chargers in seven career regular season games.
Philip Rivers and the Chargers are coming off a tough loss on the road against the San Diego Chargers. Some home cooking against Manning is just what the doctor ordered for this team to get back on track.
I expect Rivers to have a big game against the Broncos secondary—a unit that has allowed nine touchdowns while only intercepting two passes so far this season.
Follow me on Twitter @JesseReed78