Cary Edmondson-US PRESSWIRE
Patriots-Cardinals gives me a little hesitation, but there's no doubt this matchup has the opportunity to be the blowout of the week.
The Vikings, for all the positive things they have showed through two weeks, are just 1-1 after playing the Jaguars and Colts to start the season. Facing the 49ers, especially from a physicality standpoint, is going to be a big step up.
Minnesota should struggle to establish anything on the ground against the best run defense we've seen in some time.
The 49ers offense, meanwhile, will cram the ball down the heart of the Vikings defense most of the afternoon. Easy win for the 49ers as they get to 3-0.
Prediction: 49ers 34, Vikings 10
Final: Vikings 24, 49ers 13