Whether teams are trying to remain in the playoff picture or build for the future, teams will attempt to pull off trades before the trade deadline at 4 p.m. EST.
Although the deadline has had a tendency to be full of lack-luster trades, this year's trade deadline could be one of the most eventful in the past few years.
With one surprising trade reported to have been completed, might there be more shocking things to come over the next few hours.
Here are a few teams that might be making some big moves later today.
Unfortunately for the Raiders they just lost their starting quarterback Jason Campbell for the season with a broken collarbone.
Now they are looking for a quarterback that will complement an explosive running game that is currently second in the NFL in yards per game.
There were also reports that the Raiders would be interested in other quarterbacks such as Kyle Orton and David Garrard, but as of right now it looks like Palmer's will be a raider.
This is one of, if not the biggest, trades that will happens at the deadline. Although the Raiders will acquire a season veteran in Palmer, they are also losing another draft pick in the 2012 draft which can really hurt the team over the next few years.
The Philadelphia Eagles have obviously have played below expectations. At 2-4 they are in the cellar of the NFC East, but their Week 6 performance against the Washington Redskins showed the NFL that they are not calling it quits on the season.
Despite having the best running attack in the NFL and one of the best passing stats in the league the Eagles defense has been a real weak spot. With three fourth quarter collapses against the Atlanta Falcons, New York Giants, and San Francisco 49ers, the Eagles' defense is in dire need of a leader.
Not many people expected the defense to struggle, especially with the offseason acquisitions of defensive lineman Cullen Jenkins, cornerback Nnamdi Asomugha and cornerback Dominique Rodgers-Cromartie.
Look for the Eagles to make a move before the trade deadline to help salvage their season.
Every one knows about the Detroit Lions' explosive passing attack with quarterback Matt Stafford and MVP candidate Calvin Johnson, but the running game has really struggled.
The Lions are currently 25th in the league averaging 90.8 rush yards a game and are pretty thin at the running back position.
They are currently without their second-round draft pick Mikel Leshoure who is on injured reserve with a torn achilles, and running back Jahvid Best suffered his second concussion of the season in the Lions' loss to the 49ers.
If the Lions want to remain in the playoff picture and play alongside the dominant Green Bay Packers, they will need to make a move before this afternoon. It will be difficult to rely solely on their passing game for the remainder of the season.
The Denver Broncos have been looking to trade Kyle Orton for the past two years, but they have been unable to pull the trigger.
At 1-4 the Broncos have benched their starting quarterback and put fan favorite Tim Tebow in under center.
With the chances of the Broncos making the playoffs or even being .500 looking mighty grim and with Orton in his final year of his contract, now might be the right time to rid themselves of their veteran quarterback.
With wide receiver Brandon Lloyd already out the door in Denver, Kyle Orton may be next.
After having a great 2010 year with the Cleveland Browns, Peyton Hills' hasn't been as effective this year. The Browns are currently 30th in the league in rushing yards per game.
Although Hillis and the Browns were in the midst of contract negotiations it has been rumored that Hills has requested a trade because the franchise is refusing to give him a long term deal.
Despite being one of the faces of the franchise, the Browns at 2-3, might be looking to sell their running back if the price is right.