This game represents the first of six important matchups against NFC-West opponents for the Cardinals.
These inter-conference games will be the real keys to whether the Cardinals are able to advance to the postseason this year.
A win against Seattle will be a step in a good direction, giving Arizona a satisfactory 2-1 record to start the season and helping them to potentially start to push ahead of the rest of the division.
A loss, on the other hand, will put them at just 1-2—tied with Seattle, and with the possibility of falling behind the St. Louis Rams early in the season.
Here are six things to watch for at game time that could potentially make or break the game for the Cardinals.