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Two high-powered offenses will meet each other to do battle.
Tom Brady threw for 517 yards last weekend, one of the few quarterbacks in history to do so. Phillip Rivers struggled in his first game, but nothing can keep a quarterback of his caliber down for long.
The Chargers and Patriots have played twice in 2008 and once last year. New England has won two of the three, including a nail-biter last year that they pulled out by three points.
This game will come down to how well the defenses are able to respond to these dangerous offenses.
Both teams struggle containing the run, and with the special teams gaffes the Chargers are already having, this game could get interesting quickly.
Either team could come back from a 14-point deficit with ease. This one won't be decided until the late fourth quarter.
Pick: New England 27, Chargers 21