Unfortunately for the G-Men, they left Washington winless and disappointed.
The Giants entered the season with many questions surrounding them, and left just about all of them unanswered, leaving their fans scratching their heads.
Here is a look at some of the questions the Big Blue left unanswered after Week 1.
Eli Manning lost two of his biggest targets this offseason.
While Hakeem Nicks and Mario Manningham are both excellent young receivers, those two alone are not enough to carry the load.
It started early on, when preseason stud Victor Cruz let a pass slip right through his hands, and it was downhill from there.
The G-Men went 1-10 on 3rd down, a stat that must change if they ever plan on winning games.
Its safe to say that Eli Manning is probably missing some of his old teammates right about now.
He spent most of his day on Sunday either running away or in the dirt, and there were no signs of improvement.
The Giants were never able to get a groove going on offense, thanks in part to the play of the offensive line.
After losing on a walk-off punt return to end last season, its hard to think things can get any worse. Think again.
Sure, they didn't lose the game solely because of their special teams, but they definitely did not help.
The punting was awful, kick-returns were subpar and Lawrence Tynes had a critical field goal blocked.
The G-Men will have to improve their special teams if they plan on making any noise this season.
When it comes to doubters, Eli Manning is in contention for the league lead.
Always in the shadow of his older brother Peyton, Eli was at a disadvantage the second he stepped into the league. This season is no different.
If Sunday was any indication as to how the season is going to play out, it looks like it may be a long one for the Big Blue.
Manning didn't look awful, but it is going to be tough for him to put that entire offense on his back without Steve Smith and Kevin Boss.
Only time will tell if he can lead the Giants back to the playoffs.