While both teams have not made the playoffs since the 2002 season, the two squads look to enter the 2011 season hoping things will be different this time around. The Raiders made major strides in developing their offense after finishing 8-8, while the 'Niners sputtered in the final season of coach Mike Singletary.
While the outcome of the game will have little overall importance, fans of both teams know there is a high level of pride that always comes into play when the two meet. The game will also give an edge in the preseason exhibition rivalry, which is currently tied at 19-19.
Here are six things to watch for during Saturday's action.