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Obviously I cannot predict the future, but the amount of injuries that killed the Giants the past two seasons were random and not suffered by guys who are known to be injury prone.
All the defenders that suffered injuries in 2009 stayed healthy—Mathias Kiwanuka was the only major injury to the defense—but in 2010 the offensive side of the ball took the hit.
Steve Smith, William Beatty, Ramses Barden, Domenik Hixon, Victor Cruz, Hakeem Nicks, Kevin Boss, David Diehl, Shaun O'Hara, and Madison Hedgecock all missed time due to injury, most of them missed significant time.
None of these injuries were serious, other than Barden's, Smith's and Rich Seubert's injury he suffered in the final game of the year, so we can expect all of the Giants to come back healthy and ready to make this offense elite.
Barden claims he is healthy as a horse and Smith's rehab is ahead of schedule. No news on Seubert yet but the Giants are expected to draft a high profile inside lineman in this year's draft in case Seubert cannot go.
If the Giants can avoid the injury bug, they are ready to get back to post season play.