Garcon was held out of practice at the Colts' facility on Thursday and Friday due to a hamstring injury. Although a decision on Garcon was expected on Sunday, the early decision to sit him this week is not surprising considering his inability to participate in practice this week.
Hamstring injuries tend to linger, especially in players like wide receivers who require explosiveness to be effective. Keep an eye on Garcon's practice participation next week to get a feel for whether he will be available for Week 4.
So besides benching Garcon on your fantasy squad, how else does this impact fantasy football?
Garcon has had a rough start to the season through the first two weeks. After only converting on 30 percent of his 10 targets in Week 1, QB Peyton Manning only threw Garcon's way two times in Week 2. It will be interesting to see how Manning works Garcon back in to the receiving rotation when he returns.
To replace Garcon at WR this week, the Colts signed rookie WR Blaire White from their practice squad. It is yet unclear how the Colts will incorporate White in to the offense on Sunday, but White has very good hands and runs defined routes, making him an ideal slot receiver.
In very deep leagues, you could take a shot on White if you are absolutely desperate at wide receiver.
In all likelihood, the Colts will slide current slot receiver Austin Collie to Garcon's position on the outside, moving TE Dallas Clark to the slot on most plays. Clark would then be replaced by TE Brody Eldridge on plays calling for tight end blocking.
Everything depends on Manning's comfort level with White. While White did go through training camp with the Colts, so he and Manning likely have some familiarity, White has spent the last three weeks on the practice squad, away from Manning and the first-team offense.
If Manning feels comfortable with White in the slot, Clark may continue to line up at tight end, with Collie sliding out as described above. But as we all know, it's Manning's call.
Colts WR Reggie Wayne will be covered by CB Champ Bailey, if Bailey is available. Bailey is fighting through a foot injury, and will be a game-time decision. Through two games, Baily has shut-down Jaguars WR Mike Sims-Walker and Seahawks WR Mike Williams. Wayne is more talented than both Sims-Walker and Williams combined, but be aware that Wayne may have a bit of a down day.
Look for Collie and Clark to have big target totals at the end of the day. If Clark does line up in the slot, he presents matchup problems for both linebackers and cornerbacks due to his size.
Manning, Wayne, Clark, and Collie are all must starts on your fantasy squad on Sunday. If you own one or more Colt players, you'll be smiling on Sunday night.
Best of luck to you this weekend. May your domination continue, or your comeback begin.
For more fantasy football related chatter, you can follow Nathan on Twitter at @nathanwaddell.