NFL Predictions Week 5: Every Game's Odds, Lines and Score Predictions

Sometimes in the NFL, the outcome of one week's game doesn't seem to have much effect on the odds for the next game on the schedule. 

For instance, if you're the New England Patriots and you have your star quarterback coming back from suspension in Week 5, you can be a 10-point favorite even if you put up zero points on a division rival in Week 4. 

Or, if you're the Arizona Cardinals and you've dropped two games straight, most recently to the Los Angeles Rams, and looked asleep at the wheel while doing so, you still find yourself a two-and-a-half-point favorite over the San Francisco 49ers.  

Let's take a look at all the other point spreads for Week 5's slate of games, as well as the safest bet this week and a big gamble, especially if you're picking straight up. 

Note that the Jacksonville Jaguars, Kansas City Chiefs, New Orleans Saints and Seattle Seahawks have a bye in Week 5.  

Date	Away	Home	Point Spread	Score Prediction
Oct. 6	ARI	SF	ARI -2.5	17-14, Cardinals
Oct. 9	NE	CLE	NE -10	21-10, Patriots
Oct. 9	PHI	DET	PHI -1	28-13, Eagles
Oct. 9	CHI	IND	IND -4.5	20-14, Colts
Oct. 9	TEN	MIA	MIA -3.5	17-10, Dolphins
Oct. 9	WAS	BAL	BAL -4	27-24, Ravens
Oct. 9	HOU	MIN	MIN -6	28-21, Vikings
Oct. 9	NYJ	PIT	PIT -7	35-17, Steelers
Oct. 9	ATL	DEN	DEN -6.5	27-21, Broncos
Oct. 9	CIN	DAL	DAL -1.5	24-20, Bengals
Oct. 9	BUF	LA	LA -3	16-14, Rams
Oct. 9	SD	OAK	OAK -3.5	30-27, Raiders
Oct. 9	NYG	GB	GB -7	28-20, Packers
Oct. 10	TB	CAR	N/A	28-10, Panthers

Safest Best: New England (-10) over Cleveland

Elise Amendola/Associated Press

Sure, the Patriots came up with nothing against the Buffalo Bills in Week 4, suffering their first loss of the season as the Bills defeated them 16-0. 

But there's no reason to believe that the Pats won't continue their winning ways when quarterback Tom Brady returns in Week 5 to take on the Cleveland Browns. 

Needless to say, Browns coach Hue Jackson isn't looking forward to that prospect, as Mary Kay Cabot of Cleveland.com shared:

Under rookie backup quarterback Jacoby Brissett, New England's offense looked anemic. The Patriots failed to convert a third down for three quarters of the game and, obviously, failed to find the end zone at all. 

But we've seen, both in Brissett's previous outing as well as under second-stringer Jimmy Garoppolo, how high-octane this offense can be with its myriad weapons, from wide receiver Julian Edelman to tight end Rob Gronkowski to running back LeGarrette Blount. 

And so it will be again, under Brady and against Cleveland. 

It's no secret Bills head coach Rex Ryan seems to have the Patriots' number. Buffalo defeated New England 17-9 in Week 17 last season. 

And the Browns defense is no Bills defense. Buffalo is currently ranked sixth in scoring defense, allowing just 17 points per game on average.

The Browns are far more generous, allowing opponents an average of 28.8 points per game. That puts them at 27th in the league overall. 

As for the Patriots defeating the Browns by more than 10 points, New England is averaging 20.3 points per game even if you take their goose egg on Sunday into consideration. Cleveland, on the other hand, is averaging 18.5. 

That alone may not convince you to take New England to cover the spread. But the Patriots defense, which is allowing just 15.3 points per game, is better equipped to limit Cleveland's offense than the Browns are to hold off New England's. 

Biggest Gamble: Dallas (-1.5) over Cincinnati 

Gary Landers/Associated Press

The Cincinnati Bengals are only at .500 on the season, winning their first game since Week 1 over the Miami Dolphins on Sunday. 

The Dallas Cowboys, meanwhile, have strung together three consecutive wins after losing their season opener to the New York Giants. 

Still, the Cowboys are such a small favorite over the Bengals to open the week that if you're picking straight up, there's not much reason to feel overly confident about Dallas defeating the Bengals in Week 5. 

After all, when the Bengals are on, they're on. Just look at what star wideout A.J. Green can do; he had 10 receptions for 173 yards and a touchdown against the Dolphins. 

That's more yards than Miami put up total. 

Much of the Bengals' success depends on the arm of Andy Dalton. He hasn't thrown more than one touchdown in a game this season and has often matched that one score with an interception, which makes it difficult for Cincinnati to put up big points. 

However, Dalton posted his second-highest passer rating of the year on Sunday (111.8). And on the other side of the ball, the Bengals defense, led by a newly returned Vontaze Burfict, looked stout against Miami. 

Can it do the same thing against Dallas? Things weren't looking good early on for the Cowboys on Sunday as they fell in a 14-point deficit against the San Francisco 49ers. 

They eventually got back into the game, relying heavily on the legs of Ezekiel Elliott to do so, but the offense looked underwhelming without star wideout Dez Bryant. 

Quarterback Dak Prescott will hope for Bryant's return in Week 5 to make his task of beating the Bengals easier.

If you're looking for underdogs this week, Cincinnati seems like a solid bet. 

Odds via Odds Shark and current as of Monday, Oct. 3.